Bioavailability & optimum delivery - Learning from Pharma

Bioavailability & optimum delivery - Learning from Pharma

26 Oct 2017, 11:50 - 12:20

Grange Tower Bridge Hotel


To be efficacious and to satisfy the requirements for claim substantiation, a cosmeticformulation must achieve effective targeting of an active in the skin. Although the basic principles governing the skin permeation and disposition of molecules have been known for many years, attention has been far less focused on the role of the vehicle, particularly at cosmetically relevant doses.

This presentation will discuss the necessity to understand the fate of theformulationcomponents as well as the active once applied onto skin. Recent data confirm that the residence time of theformulation constituents can have a profound impact on the fate of the active.

Approaches to identify the ideal vehicle for skin delivery will be considered critically. Examples will be provided where the optimal vehicle for skin delivery is selected for the active based on matching polarity/solubility. Finally, the emerging importance of techniques that probe how the vehicle distributes in and on skin is highlighted.



  • Majella Lane


    Director, Skin Research Group

    UCL School of Pharmacy

    Dr. Lane's areas of expertise include delivery of actives to the skin, biophysical approaches towards the elucidation of active-excipient and...

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